Searchable abstracts of presentations at key conferences in endocrinology

ea0011p236 | Cytokines and growth factors | ECE2006

The effect of growth hormone replacement on the diurnal and ultradian dynamics of ghrelin and leptin in adult growth hormone deficiency

Joseph F , Brabant G , Ahmad A , Durham B , Fraser WD , Vora JP

Rhythmic, timed secretion of ghrelin and leptin is integral to the intricate temporal interplay of hormonal signals that maintains energy balance, feeding and body weight. Growth hormone replacement (GHR) in adult growth hormone deficient (AGHD) patients has been shown to alter body composition, energy balance and insulin sensitivity with changes in leptin secretory pattern and concentration. With GHR, single time point ghrelin concentrations have been shown to either increase...

ea0007p2 | Bone | BES2004

Does leptin regulate bone turnover in adult growth hormone deficiency?

Joseph F , Ahmad A , Wallace A , White H , Durham B , Fraser W , Vora J

Leptin stimulates osteoblastic cell proliferation, differentiation and mineralisation and inhibits osteoclast generation; leptin secretion and bone turnover are altered in adult growth hormone deficiency, a condition associated with osteoporosis. The aim of this study was to investigate leptin circadian rhythm and its association with bone turnover in untreated AGHD and following growth hormone replacement (GHR).We sampled peripheral venous blood at half...

ea0007p5 | Bone | BES2004

Growth hormone replacement is important for the restoration of PTH circadian rhythmicity in older adult growth hormone deficient patients

White H , Ahmad A , Joseph F , Prabhakar V , Patwala A , Whittingham P , Durham B , Fraser W , Vora J

Adult Growth Hormone Deficiency (AGHD) is associated with osteoporosis. PTH circadian rhythmicity is important for bone remodelling. Abnormalities in PTH circadian rhythms, including a blunted nocturnal rise, have been reported in AGHD and may contribute to osteoporosis development. GH replacement (GHR) results in improvement of PTH circadian rhythmicity and bone mineral density (BMD). In health, increasing age is associated with declining GH secretion and the appropriateness ...

ea0007p6 | Bone | BES2004

Parathyroid hormone and phosphate circadian rhythms are altered in osteopaenic adult growth hormone deficient patients

White H , Ahmad A , Joseph F , Chandran S , Corlett P , Durham B , Fraser W , Vora J

Alterations in PTH circadian rhythmicity have previously been reported in Adult Growth Hormone Deficiency (AGHD) and may contribute to the pathogenesis of AGHD-related osteoporosis. However, changes in PTH circadian rhythm have not been correlated with bone mineral density (BMD) in AGHD. Serum phosphate is a likely determinant of PTH rhythm. We examined the PTH and phosphate circadian rhythms in AGHD patients with reduced (defined as femoral neck T-score <-1.0) and normal B...

ea0007p25 | Cytokines and growth factors | BES2004

Effects of long term growth hormone replacement on leptin and body composition in adult growth hormone deficiency

Joseph F , Ahmad A , Wallace A , White H , Durham B , Fraser W , Vora J

Growth hormone (GH) and leptin regulate body composition and leptin is elevated in adult growth hormone deficiency (AGHD), a syndrome characterised by increased adiposity. We have previously shown that GH replacement for 1 month reduces 24-h mean leptin concentration independent of changes in fat mass. The long tem effects of GHR on leptin have not been described.24-h mean total leptin concentration was measured using half-hourly blood sampling, to accou...

ea0005p2 | Bone | BES2003

Effect of active acromegaly on parathormone circadian rhythm and phosphocalcium metabolism

White H , Ahmad A , Whittingham P , Peter R , Prabhakar K , Durham B , Fraser W , Vora J

BACKGROUND: Acromegaly is associated with abnormal bone metabolism, characterized by increased bone turnover. In health, PTH is secreted in a circadian rhythm, which is important in bone function. However, the effect of acromegaly on PTH secretion is unclear, with previous studies reporting increased, decreased or no change in PTH concentration. Furthermore, the presence of PTH circadian rhythmicity has not been defined in acromegaly.OBJECTIVES: To determine the effect of ...

ea0005p6 | Bone | BES2003

Parathyroid responsiveness to parathyroid hormone (1-34) infusion is altered in adult growth hormone deficiency following growth hormone replacement

Ahmad A , Thomas J , White H , Hopkins M , Durham B , Fraser W , Vora J

BACKGROUND: AGHD is associated with increased prevalence of osteoporosis. Alterations in both parathyroid gland sensitivity to changes in calcium concentration and end-organ response to the effects of PTH play a role in the development of osteoporosis.OBJECTIVES: To investigate the effects of PTH (1-34) infusion on end-organ and parathyroid gland responsiveness.METHODS: 6 patients with severe AGHD were recruited. All patients were admitted, prior to commencement of GH ...

ea0004p98 | Bone | SFE2002

EFFECT OF ALTERED PTH SENSITIVITY ON BASELINE BONE MINERAL DENSITY IN PATIENTS WITH UNTREATED ADULT GROWTH HORMONE DEFICIENCY

White H , Ahmad A , Peter R , Syed A , Chandran S , Durham B , Fraser W , Vora J

BACKGROUND: Untreated Adult Growth Hormone Deficiency (AGHD) is associated with reduced bone mineral density (BMD). PTH plays an important role in bone metabolism and reports suggest that bone and renal target cell insensitivity to PTH may contribute to changes in bone turnover in AGHD.OBJECTIVES: To determine the difference in PTH and phosphocalcium metabolism in untreated AGHD patients who have normal and reduced BMD.METHODS: 13 ...